Why is mesna given ifosfamide?
Mesna helps protect your bladder to prevent irritation and bleeding. Mesna is always given with ifosfamide. Most people who have treatment with cyclophosphamide are not given doses high enough to cause bleeding from the bladder.
What is IFEX used for?
IFEX is indicated for use in combination with certain other approved antineoplastic agents for third-line chemotherapy of germ cell testicular cancer. It should be used in combination with mesna for prophylaxis of hemorrhagic cystitis.
How does mesna work with ifosfamide?
Mesna helps to protect the lining of the bladder against damage from ifosfamide. The body breaks down ifosfamide to form a product that can harm the bladder, and mesna works by making this product less harmful. However, mesna does not change ifosfamide’s anti-cancer effects.
When should mesna be given?
MESNA is given at the start and then after ifosfamide therapy. The usual dosing scheme is that the total dose of MESNA is 60% of the ifosfamide dose. It is given in 3 bolus doses of 20% of the ifosfamide dose at time 0 with the ifosfamide and then 4 and 8 hours later.
What does mesna stand for?
mesna
| Synonym: | mercaptoethane sulfonate Mesnum |
|---|---|
| Foreign brand name: | Ausobronc Filesna Mesnil Mexan Mistabron Mistabronco Mitexan Mucofluid Mucolene Uromitexan Ziken |
| Abbreviation: | MSA |
| Code name: | D-7093 UCB 3983 |
| Chemical structure: | 2-mercaptoethanesulfonic acid, sodium salt sodium 2-mercaptoethane sulfonate |
Does IFEX cause hair loss?
Temporary hair loss frequently occurs in patients using this drug. Normal hair growth should return after treatment has ended. Many people using this medication have serious side effects.
What are the side effects of vinblastine?
Side Effects Pain/redness at the injection site, nausea, vomiting, constipation, tiredness, and loss of appetite may occur. Nausea and vomiting can be severe. In some cases, your doctor may prescribe medication to prevent or relieve nausea and vomiting.
When should Mesna be given?
When do you use mesna?
Mesna is used to reduce the risk of hemorrhagic cystitis (a condition that causes inflammation of the bladder and can result in serious bleeding) in people who receive ifosfamide (a medication used for the treatment of cancer). Mesna is in a class of medications called cytoprotectants.
How is the daily dose of mesna calculated?
Mesna is given as intravenous bolus injections in a dosage equal to 20% of the ifosfamide dosage (w/w) at the time of ifosfamide administration and 4 and 8 hours after each dose of ifosfamide. The total daily dose of mesna is 60% of the ifosfamide dose. The mesna multidose vials may be stored and used for up to 8 days.
Can you use mesna in combination with ifosfamide?
Hemorrhagic cystitis can be severe and can be reduced by the prophylactic use of mesna [see Warnings and Precautions (5.1 to 5.3)] . Ifosfamide injection is indicated for use in combination with certain other approved antineoplastic agents for third-line chemotherapy of germ cell testicular cancer.
When is the best time to take mesna?
Mesna is given as intravenous bolus injections in a dosage equal to 20% of the ifosfamide dosage (w/w) at the time of ifosfamide administration and 4 and 8 hours after each dose of ifosfamide.
Are there any side effects to taking IFEX?
Ifosfamide is both nephrotoxic and urotoxic. Glomerular and tubular kidney function must be evaluated before commencement of therapy as well as during and after treatment. Monitor urinary sediment regularly for the presence of erythrocytes and other signs of uro/nephrotoxicity.