What kind of transporter is SGLT1?
+/glucose cotransporter
SGLT1, a member of the solute carrier family SLC5 [1], is a high-affinity Na+/glucose cotransporter [2]. SGLT1 transports glucose and galactose across the luminal (gut) side of enterocytes, and is the first step in the absorption of sugars from nutrients.
What drugs are SGLT1 inhibitors?
Table 1
| Compound | SGLT1 ICso (nmol/L) | Selectivity (SGLT2 vs SGLT1) |
|---|---|---|
| Empagliflozin Jardiance® | ~8300 | Open in a separate window |
| Ertugliflozin Steglatro® | ~1960 | |
| Luseogliflozin Lusefi® | ~4071 | |
| Dapagliflozin Farxiga® | ~1400 |
Is SGLT1 present in kidney?
SGLT2 (also known as SLC5A2) mRNA is almost exclusively expressed in the kidney, while SGLT1 (SLC5A1) mRNA is found mainly in the small intestine and is only expressed to a small extent in the kidney [6, 17].
What kind of transporter is the SGLT1?
SGLT1 (sodium/glucose cotransporter 1) SGLT1, a member of the solute carrier family SLC5 [1], is a high-affinity Na+/glucose cotransporter [2]. SGLT1 transports glucose and galactose across the luminal (gut) side of enterocytes, and is the first step in the absorption of sugars from nutrients.
What is the role of SGLT1 in glucose uptake?
SGLT1 (sodium/glucose cotransporter 1) SGLT1 is a 75-kDa membrane protein with 14 transmembrane α-helices, an extracellular amino terminus and an intracellular carboxyl terminus [1, 4]. SGLT1 is responsible for the sodium-dependent, active uptake of glucose across the apical membrane of the small intestine. In the kidney,…
Are there any naturally occurring competitive inhibitors of SGLT1?
Phlorizin, a naturally occurring competitive inhibitor of SGLT1 and SGLT2, provided the first insights into potential efficacy, but its use was hampered by intestinal side effects and a short half-life. Nevertheless, it was a starting point for the development of specific inhibitors of SGLT1 and SGLT2, as well as dual SGLT1/2 inhibitors.
Where is SGLT1 found in the human body?
SGLT1 (sodium/glucose cotransporter 1) It is also present in the kidney (in the latter part of renal proximal tubule), the heart, and the parotid and submandibular salivary glands [4-6]. Function, physiology, and clinically significant polymorphisms SGLT1 is a 75-kDa membrane protein with 14 transmembrane α-helices,…