What is Phosphofructokinase inhibited by?
PFK catalyzes the conversion of fructose-6-phosphate to fructose-1,6-bisphosphate in glycolysis. PFK is inhibited by ATP and citrate and positively regulated by AMP.
Is telomerase present in prokaryotes?
Telomeres are only present in eukaryotes. This is the case because eukaryotes are the only type of cell that contains linear DNA. There are telomeres on each end of the chromosomes within the nucleus of these cells. Prokaryotes, on the other hand, have a single circular strand of DNA within a nucleoid.
What does Phosphofructokinase do in glycolysis?
In glycolysis, phosphofructokinase (PFK) is a key regulator of the overall reactions. It exists as a tetramer and each subunit has two binding sites for ATP. This enzyme catalyzes the first unique step in glycolysis, converting fructose-6-phosphate to fructose-1,6-bisphosphate.
How does Phosphofructokinase regulate glycolysis?
PFK is able to regulate glycolysis through allosteric inhibition, and in this way, the cell can increase or decrease the rate of glycolysis in response to the cell’s energy requirements. For example, a high ratio of ATP to ADP will inhibit PFK and glycolysis.
What inhibits phosphofructokinase in the liver?
Pure phosphofructokinase (ATP:D-fructose-6-phosphate 1-phosphotransferase, EC 2.7. 1.11) from liver is strongly inhibited by ATP, whereas crude phosphofructokinase is only slightly inhibited by ATP.
Why is telomerase not found in bacteria prokaryotes )?
It is an enzyme that contains only a short RNA molecule. Why is telomerase not found in prokaryotes? because bacteria often have circular plasmids.
Where are telomeres found?
chromosomes
Telomeres are found at the ends of chromosomes; they provide the answer to two problems of chromosome management.
What is phosphofructokinase and its role?
phosphofructokinase, enzyme that is important in regulating the process of fermentation, by which one molecule of the simple sugar glucose is broken down to two molecules of pyruvic acid.
Why is phosphofructokinase the committed step?
The first committed step is actually phosphofructokinase because then you are committed to proceeding all the way to pyruvate, i.e. to completing glycolysis. The high affinity makes it possible to initiate glycolysis even when glucose is low. These hexokinases are allosterically inhibited by their own product, G-6P.