What are the theories regarding drug receptor relationship?
Drugs interact with receptors in a reversible manner to produce a change in the state of the receptor. This interaction can be modeled mathematically and follows the Law of Mass Action. The binding of drug and receptor determines the quantitative relationship between dose and effect.
What is the drug receptor interaction?
These are defined as proteins on or within the cell that bind with specificity to particular drugs, chemical messenger substances or hormones and mediate their effects on the body.
What are the important factors influencing drug receptor interactions?
A drug’s ability to affect a given receptor is related to the drug’s affinity (probability of the drug occupying a receptor at any given instant) and intrinsic efficacy (intrinsic activity—degree to which a ligand activates receptors and leads to cellular response).
What are the characteristics of drug receptor interactions?
As noted above, drug receptor interaction can generally be defined as specific, dose-related and saturable. These characteristics of a drug at a receptor are described by KD and ED50 and can be obtained from ligand binding and dose–response curves.
What is the two state receptor theory?
Two-state receptor theory The model uses an equilibrium dissociation constant to describe the interaction between ligand and receptor. It proposes that ligand binding results in a change in receptor state from an inactive to an active state based on the receptor’s conformation.
What is macromolecular perturbation theory?
MACROMOLECULAR PERTURBATION THEORY Suggests that when a drug-receptor interaction occurs, one of two general types of Macromolecular perturbation is possible: a specific conformational perturbation leads to a biological response (Agonist), whereas a non specific conformational perturbation leads to no biological …
What is the difference between half-life and duration?
The duration is the time period and the half-life of a radioactive substance is the duration for half of the atomic nuclei of the radioactive sample of the substance to decay.
What is the difference between half life and duration?
Which kind of drugs are absorbed through endocytosis?
8. Which kind of drugs are absorbed through endocytosis? Explanation: Macromolecular drugs, Drugs as solid particles and drugs as oily particles are absorbed through endocytosis.
What is spare receptor theory?
A certain number of receptors are “spare.” Spare receptors are receptors that exist in excess of those required to produce a full effect. DOSE-RESPONSE CURVES. Dose-response relationships are a common way to portray data in both basic and clinical science.