What are the applications of mass spectrometry?
Specific applications of mass spectrometry include drug testing and discovery, food contamination detection, pesticide residue analysis, isotope ratio determination, protein identification, and carbon dating.
Which analyzer is more significant TOF or quadrupole?
More precisely, ions gain kinetic energy that is proportional to their charge Q. For ions with the same charge, E/Q is approximately constant. Therefore, ions with smaller m/Q fly more quickly through the TOF chamber and reach the detector earlier.
What are two applications of mass spectrometry?
Why is mass spectrometry useful?
Mass spectrometry is an analytical tool useful for measuring the mass-to-charge ratio (m/z) of one or more molecules present in a sample. These measurements can often be used to calculate the exact molecular weight of the sample components as well.
What is the purpose of coupling a quadrupole and TOF?
Q-TOF mass spectrometers combine TOF and quadrupole instruments, a pairing that results in high mass accuracy for precursor and product ions, strong quantitation capability, and fragmentation experiment applicability.
How does a quadrupole work?
Principle of operation The quadrupole consists of four parallel metal rods. Each opposing rod pair is connected together electrically, and a radio frequency (RF) voltage with a DC offset voltage is applied between one pair of rods and the other. Ions travel down the quadrupole between the rods.
What is a quadrupole mass analyzer used for?
Quadrupole mass analyzers are often used for targeted, quantitative applications and can be used either to measure one or a few given ions in a mixture, or to scan across a range of m/z values. Depending on the configuration, they can facilitate both MS and MS/MS applications.
What is a quadrupole used for?
As the name implies, it consists of four cylindrical rods, set parallel to each other. In a quadrupole mass spectrometer the quadrupole is the mass analyzer – the component of the instrument responsible for selecting sample ions based on their mass-to-charge ratio (m/z).
How does a TOF analyzer work?
The principle of ToF mass analyzer involves the separation of ions based on the time it takes for the ions to travel through a flight tube with known length and reach the detector.