Is SDF-1 a growth factor?
Stromal cell-derived factor 1alpha (SDF-1alpha) induces gene-expression of early growth response-1 (Egr-1) and VEGF in human arterial endothelial cells and enhances VEGF induced cell proliferation. Cell Prolif.
What is SDF disease?
Background: Peripheral artery disease is a potentially incapacitating disease for which pharmacological options are limited. Stromal cell-derived factor-1 (SDF-1) is a chemokine that attracts endothelial progenitor cells and promotes angiogenesis.
Is SDF-1 a Cytokine?
SDF-1, a novel cytokine from alpha-chemokine family, plays a key role in regulation of haematopoiesis. It exists in two forms (alpha and beta) that originate from alternative splicing.
What does CXCL12 stand for?
C-X-C motif chemokine ligand 12
Stromal cell-derived factor 1
| CXCL12 | |
|---|---|
| Aliases | CXCL12, IRH, PBSF, SCYB12, SDF1, TLSF, TPAR1, C-X-C motif chemokine ligand 12 |
| External IDs | OMIM: 600835 MGI: 103556 HomoloGene: 128606 GeneCards: CXCL12 |
| showGene location (Human) | |
| showGene location (Mouse) |
What type of protein is sdf1?
cell-derived factor-1
Stromal cell-derived factor-1 (SDF-1) is a secreted 89-amino acid protein that binds chemokine receptor type 4 (CXCR4), a seven-pass G-protein-coupled membrane receptor. Several cell types, including osteoblasts, fibroblasts, and endothelial cells, express SDF-1.
What is sdf1 Alpha?
Stromal cell-derived factor 1 alpha (SDF-1α) is a member of the CXC group of chemokines that binds to the G-protein coupled receptor, CXCR4, to regulate migration, proliferation, differentiation, and survival of many cell types including hematopoietic stem cells, B cells, and T cells.
What is cellular stroma?
Stromal cells, or mesenchymal stromal cells, are differentiating cells found in abundance within bone marrow but can also be seen all around the body. Stromal cells can become connective tissue cells of any organ, for example in the uterine mucosa (endometrium), prostate, bone marrow, lymph node and the ovary.
Where is CXCR4 located?
CXCR4 is a G-protein-coupled seven transmembrane receptor that was originally cloned as an orphan chemokine receptor and was known as LESTR or fusin. CXCR4 is expressed on the cell surface of most leukocytes, including all B cells, and monocytes and most T lymphocyte subsets, but just weakly on NK cells.
How big is the Macross?
| SDF-1 Macross | |
|---|---|
| Original Designer | Kazutaka Miyatake |
| Preproduction name | Megaroad / Megaload |
| Length | 1210 m |
| Operational Mass | 18,000,000 t |
What is the breast stroma?
Sclerotic stroma of the Breast. Sclerosis refers to a condition of ‘hardening’ of some kind, usually caused by an overgrowth of fibrous tissue. ‘Stroma’ is a general term which refers to the supportive-connective tissues surrounding or within an organ, as opposed to the more ‘functional’ elements.
Are stromal cells cancerous?
Stroma is made up of the non-malignant cells, but can provide an extracellular matrix on which tumor cells can grow. Stromal cells may also limit T-cell proliferation via nitric oxide production, hindering immune capability.
Where is SDF-1 expressed in the bone marrow?
SDF-1 is a naturally occurring chemotactic factor that is normally expressed in the bone marrow space by the stromal cells. Stromal cell-derived factor (SDF)-1α (CXCL12) belongs to the subfamily of CXC-chemokines, which are small secreted chemotactic cytokines.
What are the functions of SDF-1 in stem cells?
Several cell types, including osteoblasts, fibroblasts, and endothelial cells, express SDF-1. SDF-1 binding activates multiple signaling pathways involved in adhesion and migration, including FAK, PI3K, MAPK/Erk kinase (MEK), and Jak/Tyk2, and it is important in stem cell migration and proliferation.
How does SDF-1 Alpha bind to proteoglycans?
SDF-1-beta (3-72) and SDF-1-alpha (3-67) show a reduced chemotactic activity. Binding to cell surface proteoglycans seems to inhibit formation of SDF-1-alpha (3-67) and thus to preserve activity on local sites. Also binds to atypical chemokine receptor ACKR3, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1.
Are there any clinical trials for SDF-1?
A phase 1 clinical trial (NCT01082094) showed no overt safety issues associated with gene transfer of plasmid DNA encoding human SDF-1. 13 A randomized double-blind placebo-controlled phase 2 clinical trial is underway to determine the efficacy of endomyocardial injection of plasmid SDF-1 in CHF (NCT01643590). Julia C. Chen,