Why are liposomes used for drug delivery?
Liposomes protect some drugs against chemical and immunological breakdown, as well as protecting them against the effect of enzymes. Liposomes give lowered toxicity and lower dosing because of sustained drug levels, especially when so called “stealth” liposomes are used [38].
Which properties of liposomes helps in drug delivery?
As a drug delivery system, liposomes offer several advantages including biocompatibility, capacity for self-assembly, ability to carry large drug payloads, and a wide range of physicochemical and biophysical properties that can be modified to control their biological characteristics (Koning and Storm, 2003; Metselaar …
What is liposome delivery system?
Liposomes are consisted of single or multiple lipid bilayers formed by hydrophilic and hydrophobic interactions with the aqueous phase. Two important advantages of liposomes, in drug delivery of living organisms, are biocompatibility and biodegradability, which are due to lipid characteristics.
What potential use of liposomes can you imagine in drug delivery?
Liposomes have been extensively studied and are used in the treatment of several diseases. Liposomes improve the therapeutic efficacy by enhancing drug absorption while avoiding or minimizing rapid degradation and side effects, prolonging the biological half-life and reducing toxicity.
Are liposomes expensive?
Various microscopy techniques, including cryo-TEM, have also been found useful for the characterization of liposome size. The result is exact information about the profile of the liposome population over the whole range of sizes. Unfortunately, these techniques are very expensive and require specific equipment.
What are the clinical application of a liposomal drug delivery system?
They have been explored in the clinic for applications as diverse as imaging tumors and sites of infection, for vaccine and gene medicine delivery, for treatment of infections and for cancer treatment, for lung disease and for skin conditions.
Why do liposomes become an attractive choice to overcome drug resistance?
Due to the similarity of the liposome structure and composition to the bacterial membrane, they have the unique capacity to interact with the bacteria, stimulate fusion with the cell membrane, enable a high antibiotic delivery into the bacteria and potentially overcoming antibiotic resistance mechanisms [13].
How are liposomes used in ophthalmic drug delivery?
Liposomes have been investigated for ophthalmic drug delivery since it offers advantages as a carrier system. It is a biodegradable and biocompatible nanocarrier. It can enhance the permeation of poorly absorbed drug molecules by binding to the corneal surface and improving residence time.
Which is a model drug for ocular drug delivery?
In this study, we used CHR and BBH as the model drugs for a novel ocular drug-delivery system consisting of PAMAM and liposomes.
What causes poor ocular bioavailability after liposome instillation?
Factors responsible for poor ocular bioavailability following topical instillation are precorneal drainage and lipoidal nature of the corneal epithelium. In addition, a major fraction of drug reaches the systemic circulation through conjunctival vessels and nasolacrimal duct, which leads to severe adverse effects.
Why is drug delivery difficult in the eye?
Ocular drug delivery is challenging in terms of achieving optimum drug concentration due to unique protective mechanisms of the eye. Development of a drug delivery system for attaining therapeutic concentration at the target site requires a comprehensive understanding of static and dynamic barriers of the eye.